Tuesday, December 24, 2019

Application and advantages of titanium alloy materials in cardio-cerebral vascular repair materials

Examples of titanium and titanium alloys in human cardiovascular applications include artificial heart valves, blood filters, pacemakers, and artificial heart pumps.
Its advantages are:
① High strength, good chemical stability, and excellent biocompatibility;
② Titanium is non-magnetic and rarely produces artifacts in the magnetic resonance spectrum MRI;
③ The elastic ability and shape recovery function of NiTi memory alloys are very suitable for medical applications. NiTi alloys are martensitic at low temperatures (near zero) and can easily be transformed into shapes that can be easily introduced into the body. A reverse-phase change will occur when it returns to the original shape, and a large restoring force will play the role of orthopedic and support. In recent years, the application of NiTi shape memory alloys on vascular stents has attracted much attention. However, NiTi alloys may dissolve Ni ions under physiological conditions, thereby inducing toxicity and inflammatory reactions. To this end, researchers have carried out a large number of surface modification studies on the alloy. The main methods are surface inert coating, surface oxidation, surface activation, and surface grafting of macromolecules. Although their footholds are different, they can effectively inhibit the dissolution of Ni ions and improve the corrosion resistance and biocompatibility of NiTi alloys. According to relevant data, the incidence of rheumatic heart disease in adults in China is 2.34% to 2.72%, and about 1.9 million adult rheumatic heart disease patients are estimated based on the total population. Approximately 250,000 patients need artificial heart valve replacement surgery due to severe valve disease. The actual artificial heart valve usage is only 25,000. The domestic demand is about 30%. The annual demand for pacemakers is about 400,000. 20,000 units, the domestic production rate is only 1%, while the domestic production rate of coronary stent products is higher, reaching about 50%.
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